RMC Synthesis and Biological Effects of Nitrogen Heterocyclic Chromenons Compounds

The synthesis of chromenones, aromatic fused heterocyclic compounds consisting of a chromenones and a pyridine ring, has been associated with various biological activities. In this study, we have devised a novel, uncomplicated, and more broadly applicable method for the multicomponent reaction synthesis (RMCs) of chromeno-pyridins[1] and its analogues, while adhering to select criteria of green chemistry. Our approach involves the synthesis of chromenons from hydroxyacetophenones, crucial components contributing to the diversity of structures achieved through the utilization of primary amines[2]. Subsequently, the newly prepared compounds were characterized through diverse spectroscopic analyses, including IR, 1H NMR, 13C NMR, and MS. To evaluate the antifungal efficacy of our products, we chose to assess them against a specific fungal strain,namely Aspergillus niger. The results of the antifungal activity, determined through the solid-state dilution method, yielded positive outcomes gave good results.