SUBSTANTIATION OF MULTI-COURSE ENTEROSORPTION AIMED AT MINIMIZING THE NEGATIVE EFFECT OF CHRONIC INTOXICATION IN THE EXPERIMENT
The markers for assessing the dynamics of chronic hepatotoxicity, which has a 3-stage character, as well as the effectiveness of a single course and multi-course enterosorption (ES) have been substantiated using the chronic toxic liver damage (CTLD) model induced by carbon tetrachloride (CCL4). The terms when the CTLD model was made were 26 days (stage 1), 10-20 weeks (stage 2), and 36 weeks (stage 3) since the CCL4 intoxication. Serum aminotransferase activity (ALT, AST), bromsulfalein test values, hexenal-induced sleep duration, medium-weight molecules (MWM) content, serum toxicity level, malondialdehyde (MDA) content in the liver tissue, mitochondria and lysosomes of hepatocytes quantification by electron microscopy were studied.
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