SUBSTANTIATION OF MULTI-COURSE ENTEROSORPTION AIMED AT MINIMIZING THE NEGATIVE EFFECT OF CHRONIC INTOXICATION IN THE EXPERIMENT

The markers for assessing the dynamics of chronic hepatotoxicity, which has a 3-stage character, as well as the effectiveness of a single course and multi-course enterosorption (ES) have been substantiated using the chronic toxic liver damage (CTLD) model induced by carbon tetrachloride (CCL₄). The terms when the CTLD model was made were 26 days (stage 1), 10-20 weeks (stage 2), and 36 weeks (stage 3) since the CCL₄ intoxication. Serum aminotransferase activity (ALT, AST), bromsulfalein test values, hexenal-induced sleep duration, medium-weight molecules (MWM) content, serum toxicity level, malondialdehyde (MDA) content in the liver tissue, mitochondria and lysosomes of hepatocytes quantification by electron microscopy were studied.