Chapter 5: Role of Overall Treatment Time in Radiotherapy Management of H&N Cancer

Here we demonstrated that uncertainty and inaccuracy in TCP/NTCP estimation increases as move away from conventional dose fractionation schedules. The biological input parameters derived from conventional dose fractionation schedules should be cautiously used while calculating NTCP for moderately hypo-fractionation and accelerated fractionation schedules in head & neck cancer. There is significant impact of OTT and it should be considered when evaluating TCP/NTCP for early responding tissue. In present study, role of overall treatment time in accelerated fractionation and altered fractionation regimens demonstrated. Overall treatment time (OTT) plays significant role while assessing toxicity in early responding tissue and OTT affects the tumor control probability.