Chapter 4: Problem Based Application of Developed Program for TCP & NTCP Estimation

This chapter discussed the applications of radiobiological (RB) models in different clinical scenarios for estimating TCP and NTCP. This chapter focuses on the scope of spinal cord tolerance dose revision in intensity modulated SIB treatment plans of locally advanced H&N cancer. In this chapter author tried to demonstrate that how tolerance dose limit for spinal cord (late responding tissue) is overestimated during plan evaluation. This demonstration performed based on both dosimetric as well as biological parameters.