Chapter 3: Development of an Indigenous Radiobiological Model Based TCP and NTCP Estimation Software for Routine Plan Evaluation in Clinics

Chapter-3 discussed the process of development of software/program used to calculate biological indices TCP and NTCP for biological model based plan evaluation. In addition, cross validation of output of developed software with Bio-suite software also performed. In radiotherapy, there is ongoing practice of plan evaluation is based on dose volume histogram (DVH). DVH is a two dimensional representation of three dimensional dose distribution. However, design of treatment plan outcome based on biological objective functions has the potential to improve clinical outcomes. The biological objective functions are usually expressed in the form of tumour control probability (TCP) & normal tissue complication probability (NTCP). To obtain more reliable outcome, it require the knowledge of parameter values of TCP/NTCP models.