Development of Antibody-Conjugated Arsenite Embedded Nanoparticles (Nps) With Potential to Target Primary, and Chemo and Radio Resistant Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma (NPC) is a clinical, biological and histological entity that stands out from other carcinomas of the head and neck by its relationship with the Epstein Barr virus (EBV), Although radiotherapy (RT) and the radiotherapy-chemotherapy combination remain the therapies of choice for non-metastatic forms and advanced cases compared to chemotherapy alone, cases of tumor recurrences characterized by the expression of the major oncogene of viral origin (LMP1). To cope with these forms of therapeutic resistance, we are working on the preparation of a nanometric tool capable of encapsulating radio-sensitizing anticancer molecules by targeting tumor cells.The targeted addressing of the molecule allows its accumulation in the target site expressing the surface oncogene of EBV by reducing its exposure to healthy tissue. Our aim is to design a nano-vector, by simple emulsion, based on two biopolymers (sodium alginate and gelatin) to encapsulate sodium arsenite.