Synthesis and Separation of Geometrical Isomers of Hydrazone: Towards Effective Antibacterial Agents

The amine 4,4’-diamino diphenylsulfone is utilized in the synthesis of ethyl pyruvate -4,4’ dihydrazonodiphenylsulfone. This process is achieved through the conversion of the amine to its diazonium salts, followed by reduction using tin chloride to produce hydrazine. Hydrazine is then condensed with ethyl pyruvate to yield the desired hydrazone, which is subsequently separated using column chromatography to isolate the following isomers: syn–syn, syn–anti, anti–anti. The physical properties were investigated using spectroscopy methods. The pharmacological study revealed its effectiveness as an antibacterial agent.