Exploring the Potential of Azaflavanones in Annexin A5 Inhibition: A Molecular Docking Study for Anti-inflammatory Therapy

Authors

Djawhara Haddad
Bioactive Molecules and Chiral Separation Laboratory, Faculty of exact sciences, Tahri Mohammed University, Istiklal street PO 417 Bechar, 08000, Algeria
Nasser Belboukhari
Bioactive Molecules and Chiral Separation Laboratory, Faculty of exact sciences, Tahri Mohammed University, Istiklal street PO 417 Bechar, 08000, Algeria
Khaled Sekkoum
Bioactive Molecules and Chiral Separation Laboratory, Faculty of exact sciences, Tahri Mohammed University, Istiklal street PO 417 Bechar, 08000, Algeria
Meriem Bouanini
Bioactive Molecules and Chiral Separation Laboratory, Faculty of exact sciences, Tahri Mohammed University, Istiklal street PO 417 Bechar, 08000, Algeria

Synopsis

Azaflavanones, a class of flavonoids have been extensively studied for their diverse biological activities, including their anti-inflammatory properties. In this study, molecular docking was employed to investigate the potential of azaflavanones as anti-inflammatory agents by docking them with Annexin A5, a protein involved in various cellular processes and implicated in inflammation. The results revealed that azaflavanones forms stable interactions with Annexin A5, suggesting its potential as a novel anti-inflammatory agent. The findings of this study provide valuable insights into the molecular mechanisms underlying the anti-inflammatory activity of azaflavanone and pave the way for further exploration of its therapeutic potential.

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Published
December 4, 2024