Molecular Docking Analysis of 4-Iminoflavan Derivative as an Anti-Inflammatory Agent Targeting Mitogen-Activated Protein Kinase 1 (MAPK 1)

The current study focuses on the molecular docking of 4-iminoflavan derivatives obtained through a condensation reaction with a primary amine as an anti-inflammatory drug that targets Mitogen-activated protein kinase 1 (MAPK1), which is an important signaling molecule that regulates cell survival, differentiation, and proliferation. The molecular docking program used in this investigation was Moe software. The result showed the binding energy of N-(hydroxyl-Phenyl) 4-iminoflavan to MAPK1 was found to be -5.5 kcal/mol, indicating a strong binding affinity.