Formulation of an Inula Viscosa L. Plant Extract Emulgel: Phytochemical Study and Evaluation of Anti-Inflammatory and Antioxidant Activity

The proper formulation of plant extract consisting of secondary metabolites with pharmacological activities contributes to the improvement of their therapeutic activities. The methanol extract of Inula viscosa L. obtained with a yield of 18.15% per soxhlet, which is rich in secondary metabolites such as polyphenols, flavonoids and tannins. The evaluation of the anti-inflammatory activity of the extract argued an interesting anti - inflammatory effect presented by a reduction rate of edema of 27% compared to that of the reference product the diclofenac which is 77%. In addition, the evaluation of the antioxidant activity by the DPPH method of the polar extract gave us; a very interesting percentage of inhibition was recorded of the order of 85.71%, with an IC50equal to 211.79μg/ml. which shows the polyphenol richness and captivity of the radicals of the Inula viscosa L. Finally, the emugel prepared from the Inula viscosa L. extract complies with the standards required by stability tests and rheological profiles.