Greener Modifications in the Stereoselective Synthesis of 2o Alcohols


Ramakrishna D. S.
Department of Chemistry, Veer Surendra Sai University of Technology, Burla-768018, Sambalpur, Odisha, India


Stereoselective synthesis of chiral 20 alcohol was demonstrated in this work. LiH was found to be a better option in achieving higher yield and good stereoselectivity in comparision with other bases like NaH and CsH. Both hydrogenation (asymmetric vertion) and ethrification (Williamson reaction) were carried out using greener procedures (One pot synthesis). Generation of side product was minimized using this halogen solvent free greener protocol.

December 24, 2022