Photoredox-mediated Synthesis of β-Hydroxydithioacetals from Terminal Alkynes
Synopsis
A single-step visible light mediated synthesis of α-hydroxydithioacetals via oxidative coupling of terminal alkynes with thiophenol is reported. Compared to other multistep strategies, this work presents a rare tandem introduction of disulfides and hydroxy group at the β-position in one pot. The reaction is enabled by aerial oxidation, features high efficiency, mild conditions and extendable to both aliphatic and aromatic alkynes.
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Published
December 24, 2022
Series
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