Photoredox-mediated Synthesis of β-Hydroxydithioacetals from Terminal Alkynes

Authors

Farah Manzer Manhas
Department of Chemistry Shoolini University, Solan, Himachal Pradesh-173212
Jaswant Kumar
CSIR-Indian Institute of Integrative Medicine, Jammu-180001
Bhahwal Ali Shah
CSIR-Indian Institute of Integrative Medicine, Jammu-180001

Synopsis

A single-step visible light mediated synthesis of α-hydroxydithioacetals via oxidative coupling of terminal alkynes with thiophenol is reported. Compared to other multistep strategies, this work presents a rare tandem introduction of disulfides and hydroxy group at the β-position in one pot. The reaction is enabled by aerial oxidation, features high efficiency, mild conditions and extendable to both aliphatic and aromatic alkynes.

ICheEC2021
Published
December 24, 2022