Impact of COVID-19 on Neuroinflammation and Other Neurological Disorders

Coronavirus disease 2019 is an infectious disease which causes severe acute respiratory syndrome. It is expected to kill millions of people throughout the world. According to recent research, SARS-CoV-2 affects the central nervous system and other organs. Also, COVID-19-related problems have been seen in persons with neurological disorders such as stroke, Parkinson's disease, and Alzheimer's disease. On the cellular and molecular level, it has been seen that SARC-CoV-2 induces neuro-inflammation. Here we have discussed about viral replication as well as inflammation caused by SARS-CoV-2. Activation of the innate immune system is associate with increased cytokine level and free radicals in the SARC-CoV-2 induced pathogenic response at the blood brain barrier. Blood brain barrier disruption allows immune/inflammatory cells into the CNS, activating immune resident cells (such as microglia and astrocytes). We also include COVID-19-related neurological issues as well as their treatments and vaccinations for successful management. At last different receptors involved in the development of neuro-inflammation and other neurological disorders have been discussed. A better understanding of these mechanisms will help gain substantial knowledge about the potential role of SARC-CoV-2 in neurological changes and plan possible therapeutic strategies.